Games list, of some other titles which dare to do something different in a game genre that's becoming increasingly pigeonholed.

Piratical swashbucklers might want to check out two pirate-themed MMOs, Pirates of the Burning Sea and Puzzle Pirates.
Sci-fi junkies are welcomed in space-themed MMOs like Star Wars Galaxies, Anarchy Online, EVE Online and Phantasy Star Online.
Cyberpunks abound in The Matrix Online and Neocron, and upcoming title Auto Assault.
Social butterflies gravitate towards worlds like Disney's Virtual Magic Kingdom, The Sims Online, A Tale in the Desert, Second Life and Habbo Hotel.
Heroes and villains can roam the streets in City of Heroes/Villains.